Collagen Cross-Linking

Accelerated Collagen Cross-Linking (KXL)

This is a technique which uses an intense ultraviolet light (UVA) source and a photosensitising chemical (Riboflavin) to create increased linkages (cross-linking) between the cornea’s collagen fibres. This technique has been shown to be extremely successful in arresting the progression of (i.e. stabilising) the condition and occasionally even producing small improvements.

Collagen Cross Linking

Your surgeon will place anaesthetic drops in the eye to be treated and then an eyelid holder in your eye to keep it open throughout the procedure. A thin surface sheet of cells is marked by a manual cutting ring, a small amount of alcohol is then applied over this sheet to loosen it and thus enable the surgeon to roll it away from the area to be treated. The eye is then soaked in riboflavin eye drops (2 drops every 2 minutes for 10 - 20 minutes). An ultraviolet (UVA) light is then shone on the cornea for 2 - 5 minutes and the procedure is complete. You will have some drops placed in your eye and a contact lens may be fitted. This lens is for protection as well as aiding in reducing discomfort. The whole procedure usually takes about 20 - 40 minutes.

 

Accelerated cross linking

Collagen Cross Linking

After the procedure is completed, you will be given a full explanation regarding post-operative drops and tablets and follow up care. Protective eye shields will have been placed over the treated eye to prevent you from rubbing your eye for the rest of the day and also whilst sleeping during the night.

During the early post-operative period it is important not to squeeze or rub the eyes. Antibiotic and anti-inflammatory drops are used to prevent infection and decrease inflammation.

After leaving the clinic, patients are encouraged to rest/sleep for a few hours. The majority of patients will have moderate to severe discomfort beginning a few hours after the crosslinking procedure and this usually disappears within 24 - 48 hours. However, to ensure that the majority of patients have as comfortable a period after treatment as possible, all patients are given painkilling tablets to be taken every 4 – 6 hours for 1-2 days.

A post operative follow up appointment takes place at the clinic approx. 7 days after the procedure, to ensure that your eye is healing as expected. There are a few restrictions for a week or so following your procedure, but as long as you follow your doctor’s instructions, you should be free to resume all of your normal activities thereafter.

Although KXL is a short procedure, you have had an operation and should therefore try to rest and relax for the first 24 – 36 hours after treatment. The best plan is to slightly darken a room and listen to some music, rather than trying to  read or watch television. (Both reading and watching television can cause your eye to move under the patch and may make the discomfort greater.)

 

Collagen Cross Linking

Who is suitable for treatment?

Anyone who has progressive keratoconus may be suitable. Those patients with advanced keratoconus or severe scarring may not be suitable for treatment, especially if they have poor vision with contact lenses.

Is cross-linking a cure for Keratoconus?

Crosslinking is extremely successful in arresting the progression of Keratoconus. Studies have shown a success rate of more than 95% of those who have been treated. Whilst it is not a cure for the condition, it is likely to prevent the need for more invasive surgery such as corneal transplant, for at least 5 years in the majority of patients. The treatment can then be repeated if necessary.

What is the difference between your technique and traditional cross-linking?

Our accelerated crosslinking procedure takes on average 30 minutes to complete. This compares to approx.. 90 minutes for the ‘traditional’ method, which is no more effective.

 

What our patients say

I want to thank you and congratulate you and your team for the excellent and very professional treatment I recently received concerning my watering eye and the removal of a large dacryolith. It was a refreshingly different experience than that of dealing with the NHS. Read Carl's letter